Quantitative Analysis of Serum Free Light Chains
نویسندگان
چکیده
منابع مشابه
Quantitation of serum free light chains.
under usual artificial light conditions, and storage of unproc-essed whole blood without antico-agulants at room temperature on the bench. Additionally, we tested the effect of multiple freeze-thaw cycles. 25(OH)–vitamin D 3 measurements were performed on a Cobas E601 an-alyzer (Roche), using the vitamin D 3 (25-OH) assay as recommended by the manufacturer. Samples from each storage experiment ...
متن کاملQuantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease.
BACKGROUND AND OBJECTIVES Monoclonal free light chains (FLC) frequently cause kidney disease in patients with plasma cell dyscrasias. Polyclonal FLC, however, have not been assessed in patients with chronic kidney disease (CKD) yet could potentially play an important pathologic role. This study describes for the first time polyclonal FLC in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & ...
متن کاملMeasurement of immunoglobulin free light chains in serum.
but the active/latent isoform proportions were similar (Fig. 1A). Platelet aggregation during clotting (6) may have caused these differences. MMP expression was lower in K 2 E plasma than in LH plasma [14 (3) vs 25 (4) g/L; P Ͻ0.05; Fig. 1A, lane 4 vs lane 5]. The concentrations of MMP-9 forms decreased significantly with increasing amounts of K 2 E during PB collection, whereas MMP-2 was incr...
متن کاملRegarding the overestimation of serum κ free light chains.
Employment or Leadership: None declared. Consultant or Advisory Role: F.C. Wu, Organon International, Bayer Schering Pharma, Eli Lilly, Proctor & Gamble, Pierre Fabre Medicaments, Ferring Pharmaceuticals, TAP Pharmaceuticals, Ardana Bioscience, and GlaxoSmithKline. Stock Ownership: None declared. Honoraria: F.C. Wu, Organon International, Bayer Schering Pharma, Lilly ICOS, Ardana Bioscience, an...
متن کاملSerum Free Light Chain Analysis
In healthy individuals, plasma cells originating from the bone marrow produce immunoglobulin molecules composed of two heavy chains and two light chains. There are two types of light chains in humans. The κ light chains are encoded by the immunoglobulin κ locus on chromosome 2 and λ light chains are encoded by the immunoglobulin λ locus on chromosome 22 [1]. During B lymphocyte development, the...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2003
ISSN: 0002-9173,1943-7722
DOI: 10.1309/lywm47k2l8xyffb3